5-Ethylthiotetrazole (ETT) is an efficient activator for use in chemical synthesis of either DNA or RNA. ETT has excellent performance with respect to coupling times, coupling efficiency, consumption of phosphoramidites and reduction of n-1 impurities. ETT can be used for RNA synthesis with TBDMS, O-Methyl, TOM® or ACE® amidites.
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Product Overview
This solution contains 0.6 M 5-ethylthiotetrazole (ETT) in anhydrous acetonitrile. ETT is one of the most widely used activators for phosphoramidite-based oligonucleotide synthesis, known for its efficiency and compatibility across multiple synthesis platforms.
Key Features
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High-purity ETT
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Prepared in anhydrous acetonitrile
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Ready-to-use formulation
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Excellent coupling efficiency
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Suitable for DNA and RNA synthesis
Application
ETT functions as an activator in the coupling step of phosphoramidite oligonucleotide synthesis. Its thiotetrazole structure enhances reactivity with phosphoramidites, making it a trusted choice for routine and high-throughput DNA/RNA synthesis applications.
Specifications
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Concentration: 0.6 M
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Solvent: Anhydrous acetonitrile
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Format: Solution
