Hyacinth Deblocking Reagent with 3% dichloroacetic acid in toluene. A gentle, high-purity solution for 5’-DMT removal in oligonucleotide synthesis workflows.
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Hyacinth Deblocking Reagent – 3% Dichloroacetic Acid in Toluene for DNA/RNA Synthesis
Hyacinth Deblocking Reagent is a 3% (v/v) solution of dichloroacetic acid (DCA) in toluene, formulated for gentle and precise deblocking in phosphoramidite-based oligonucleotide synthesis. Used during the detritylation step, this reagent efficiently removes the 5’-DMT protecting group without overexposure or degradation of sensitive sequences.
With a lower acid concentration than standard 10% DCA solutions, Hyacinth is particularly suited for protocols where reaction control, milder conditions, or higher synthesis fidelity is essential — including long oligos or modified bases.
Key Features:
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3% dichloroacetic acid (DCA) in toluene
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Low-strength deblocking for 5’-DMT removal
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High-purity formulation for DNA and RNA synthesis
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Compatible with both manual and automated synthesizers
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Ideal for sensitive or high-precision oligo synthesis
Applications:
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Deblocking step in oligonucleotide synthesis
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Detritylation under mild conditions
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Long or modified oligo workflows
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DNA/RNA synthesis requiring slower DMT removal
Distribution:
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Available across Denmark, Sweden, Norway, and Iceland
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Fast delivery and expert support from YouDoBio
