10% dichloroacetic acid in toluene for 5’-DMT removal during oligonucleotide synthesis. High-purity deblocking reagent. Compatible with automated platforms.
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10% Dichloroacetic Acid in Toluene – Deblocking Reagent for Oligonucleotide Synthesis
This high-purity solution of 10% dichloroacetic acid (DCA) in toluene is a standard reagent used in the deblocking (detritylation) step of oligonucleotide synthesis. It effectively removes the 5’-dimethoxytrityl (DMT) protecting group from the growing oligonucleotide chain, preparing it for the next coupling cycle.
The toluene solvent provides optimal solubility and reactivity while maintaining compatibility with automated synthesizer platforms and minimizing carryover or contamination.
Key Features:
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10% (v/v) dichloroacetic acid in toluene
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Used for 5’-DMT deprotection (detritylation step)
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High purity for phosphoramidite-based DNA/RNA synthesis
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Compatible with common oligo synthesizers
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Supplied in sealed containers for reagent stability
Applications:
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Detritylation step in oligonucleotide synthesis
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DNA and RNA production workflows using phosphoramidite chemistry
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Manual or automated synthesis platforms
Distribution:
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Available throughout Denmark, Sweden, Norway, and Iceland
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Fast delivery and dedicated support from YouDoBio
