20% diethylamine in acetonitrile for efficient removal of cyanoethyl (CE) protecting groups via beta-elimination in oligonucleotide synthesis. High-purity and low moisture.
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20% Diethylamine in Acetonitrile
This ready-to-use solution of 20% diethylamine in acetonitrile (v/v) is specifically formulated for the removal of cyanoethyl (CE) protecting groups from phosphate backbones in solid-phase oligonucleotide synthesis.
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Composition: 20% diethylamine in acetonitrile (v/v)
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Function: Elimination of CE protecting groups via β-elimination
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Application: Post-synthesis deprotection of oligonucleotides
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Instrument Compatibility: Suitable for both manual and automated synthesis workflows
The formulation’s low water content ensures clean and reproducible CE removal, reducing the risk of side reactions and preserving oligo integrity — especially critical for sensitive or large-scale synthesis.
