5-Ethylthiotetrazole (ETT) is an efficient activator for use in chemical synthesis of either DNA or RNA. ETT has excellent performance with respect to coupling times, coupling efficiency, consumption of phosphoramidites and reduction of n-1 impurities. ETT can be used for RNA synthesis with TBDMS, O-Methyl, TOM® or ACE® amidites.
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Product Overview
This solution consists of 0.5 M 5-ethylthiotetrazole (ETT) in anhydrous acetonitrile. ETT is widely used as a coupling activator in the phosphoramidite method for oligonucleotide synthesis.
Key Features
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High-purity ETT formulation
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Dissolved in anhydrous acetonitrile
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Excellent activation performance
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Used in DNA and RNA synthesis
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Compatible with most synthesizers
Application
ETT enhances the coupling efficiency between nucleoside phosphoramidites and the growing oligonucleotide chain. This 0.5 M concentration offers flexibility for synthesis protocols requiring lower activator levels.
Specifications
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Concentration: 0.5 M
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Solvent: Anhydrous acetonitrile
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Format: Liquid solution
