3% DCA in methylene chloride for controlled 5’-DMT removal in oligonucleotide synthesis. A gentle, high-purity deblocking reagent suitable for sensitive workflows.
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3% Dichloroacetic Acid in Methylene Chloride – Deblocking Reagent for Oligonucleotide Synthesis
This reagent combines 3% dichloroacetic acid (DCA) with methylene chloride (dichloromethane, DCM) for use in the deblocking (detritylation) step of phosphoramidite oligonucleotide synthesis. It provides a milder alternative to standard 10% DCA solutions, offering better control over DMT removal — particularly useful when synthesizing longer or modified oligos.
The methylene chloride solvent ensures effective delivery and reactivity of DCA while supporting compatibility with common oligo synthesis platforms.
Key Features:
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3% (v/v) dichloroacetic acid in methylene chloride (DCM)
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Gentle yet efficient 5’-DMT removal
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High-purity, synthesis-grade formulation
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Ideal for long or modified oligo synthesis
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Compatible with manual and automated DNA/RNA synthesizers
Applications:
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Detritylation in phosphoramidite oligonucleotide synthesis
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Workflows requiring slower or more controlled deblocking
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Sensitive DNA or RNA synthesis protocols
Distribution:
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Available in Denmark, Sweden, Norway, and Iceland
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Supplied by YouDoBio with fast shipping and support
